Can liver toxicity occur at repeated borderline supratherapeutic doses of paracetamol?

Firstly, the 250-mg/kg dose of rectal paracetamol, which was divided into three doses per day for 3 days (each dose equivalent to 27 mg/kg) were overdoses, because the recommended dose is 10 to 15 mg/kg. However, the authors failed to pinpoint this, and instead focused on the daily dose, which in fact was only at the upper limit of the recommended daily dose. The Pediatric Dosage Handbook recommends that 10 to 15 mg/kg be given every 4 to 6 hours, and not more than five doses per day. Accordingly, the maximum dose allowed in a day is 75 mg/kg, which is about the same as the amount the patient was taking daily: roughly 80 mg/kg for 2 days and 70 mg/kg for 1 day.